Scientific References

Mechanism of Action (MOA) References

Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment Clinical Cancer Research (2015) vol 21, is. 4

Cancer Cell Metabolism: Warburg and Beyond Cell. 2008; 134:5

Cancer as a Metabolic Disease. Nutr Metab. 2010;7:7

Q&A: Cancer: Clues from cell metabolism. Nature Research. 2010; 465:7298

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. Science. 2009; 324:5930

The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci. 2016; 41:3

Metabolic requirements for cancer cell proliferation. Cancer & Metabolism. 2016; 4:16

Metabolism shapes the tumor microenvironment. ScienceDirect

Mucin Role in Cancer Survival

Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment. Clinical Cancer Research (2015) vol 21, is. 4

Muc-1 Core Protein Is Expressed on Multiple Myeloma Cells and Is Induced by Dexamethasone. Blood; 93: No 4

MUC1 activates JNK1 and inhibits apoptosis under genotoxic stress. Biochemical and Biophysical Research Communications; 440:1

MUC1 IS A POTENTIAL TARGET FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA STEM CELLS. Cancer Res. 2013; 73:17

MUC1: a multifaceted oncoprotein with a key role in cancer progression. Trends in Molecular Medicine. 2014;20:6

Mucins in cancer: function, prognosis and therapy. Nature Reviews Cancer. 2009; 9

Human MUC1 Carcinoma Antigen Regulates Intracellular Oxidant Levels and the Apoptotic Response to Oxidative Stress. JBC 2003; 278:37

Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells. Oncogene 2010; 29:20

MUC1-C Stabilizes MCL-1 in the Oxidative Stress Response of Triple-Negative Breast Cancer Cells to BCL-2 Inhibitors. Scientific Reports 2016 May 24; 6:26643

Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2

Amino Acid Uptake by Cancer Cells

Nonessential amino acid metabolism in breast cancer. Adv Biological Regulation. 2016;62

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. ScienceDirect

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. eLife 2016;5

Targeting amino acid metabolism for cancer therapy. ScienceDirect

Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime? Seminar in Cancer Biology 2005; 15:4

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Developmental Cell 2016; 36: 5

Targeting amino acid metabolism for cancer therapy. Drug Discovery Today 2017; 22:5

Amino Acid Transporters in Cancer and Their Relevance to “Glutamine Addiction”: Novel Targets for the Design of a New Class of Anticancer Drugs. Cancer Research 2015; 75:9

Cellular Processing of D-Amino Acids

The ribosome can discriminate the chirality of amino acids within its peptidyl-transferase center. PNAS 2015;112:19

Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping. Nature Reviews Cancer 2011; 11

Kinetics of Ribosome-Catalyzed Polymerization Using Artificial Aminoacyl-tRNA Substrates Clarifies Inefficiencies and Improvements. ACS Chem. Biol., 2015;10: 10

Human D-Tyr-tRNATyr deacylase contributes to the resistance of the cell to D-amino acids. Biochem. J. 2009; 417

Methoxsalen and Melanocytes and Role of Lipids in Cancer Metabolism

Melanocytes as Instigators and Victims of Oxidative Stress. ScienceDirect

What are melanocytes really doing all day long…? : from the ViewPoint of a keratinocyte: Melanocytes – cells with a secret identity and incomparable abilities. Scientific Reports. 2016;6:26643

Generation of hydrogen peroxide in the melanin biosynthesis pathway. Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics 2009; 1794: 7